I primarily use Reason 6 and Cubase 7, which are software Digital Audio Workstations (DAWs). I click most things in manually with a mouse. I usually only use keyboards for auditioning samples. My rig is an Intel i7-based workstation with 16 GB 1600MHz RAM, an Intel SSD for the operating system and DAWs, and 2 large Western Digital HDDs in RAID 0 for samples. I back everything up to a Synology NAS and online to Carbonite.
My go-to VST instruments are Spectrasonics' Omnisphere, Trillian, Stylus RMX, EastWest PLAY - Hollywood Strings, Brass and Woodwinds, anything by Native Instruments but particularly Battery and Kontakt, Damage, Phaedra, Rob Papen Predator, Sylenth, Synthmaster and Plogue Chipsounds.
I currently run 2x HP ZR30w Displays at 2560x1600 each, and monitor on KRK VXT8's. I have a few guitars but my only notable one is the Fender VG, which I record through a Line 6 POD XT. My audio interface is a Steinberg UR28M, and I also use Steinberg's awesome CC121 controller (with motorized fader and AI knob! It's crazy good.)